abstract：:Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

journal_title：Histology and histopathology

authors： Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

更新日期：2010-11-01 00:00:00

abstract：:GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Glis1-3 play critical roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Mutations in GLIS2 have been lin...

journal_title：Histology and histopathology

authors： Kang HS,ZeRuth G,Lichti-Kaiser K,Vasanth S,Yin Z,Kim YS,Jetten AM

更新日期：2010-11-01 00:00:00

abstract：:Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

journal_title：Histology and histopathology

authors： Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

更新日期：2010-10-01 00:00:00

abstract：:A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell m...

journal_title：Histology and histopathology

authors： Liao WX,Wing DA,Geng JG,Chen DB

更新日期：2010-09-01 00:00:00

abstract：:In the kidney, prostaglandin (PG) E2 is the main PG, playing important roles in maintaining homeostasis or development of pathological settings. Roles of PGE2 in renal lesions remain to be clarified. The expression patterns of PGE2 synthesis enzymes such as cyclooxygenase (COX)-1, COX-2 and microsomal PGE synthase (mP...

journal_title：Histology and histopathology

authors： Yamamoto E,Izawa T,Juniantito V,Kuwamura M,Sugiura K,Takeuchi T,Yamate J

更新日期：2010-08-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...

journal_title：Histology and histopathology

authors： Shi Z,Stack MS

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...

journal_title：Histology and histopathology

authors： Hernández-Cortés P,Peregrina M,Aneiros-Fernández J,Tassi M,Pajares-López M,Toledo M,O'Valle F

更新日期：2010-06-01 00:00:00

abstract：:An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...

journal_title：Histology and histopathology

authors： Belhocine M,Gernigon-Spychalowicz T,Jacob MP,Benazzoug Y,Exbrayat JM

更新日期：2010-05-01 00:00:00

abstract：:To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...

journal_title：Histology and histopathology

authors： Li XH,Zheng Y,Zheng HC,Takahashi H,Yang XH,Masuda S,Takano Y

更新日期：2010-04-01 00:00:00

abstract：:The purpose of our study was to elucidate pathways of genetically programmed cell death (apoptosis) in corneas with macular dystrophy. 10 corneal buttons (10 patients) with macular dystrophy and 8 buttons (8 patients) from enucleated eyes with chorioideal melanoma (controls) were analysed histologically. Immunohistoch...

journal_title：Histology and histopathology

authors： Szentmáry N,Stündl A,Szende B,Süveges I

更新日期：2010-03-01 00:00:00

abstract：:It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...

journal_title：Histology and histopathology

authors： Deregibus MC,Tetta C,Camussi G

更新日期：2010-03-01 00:00:00

abstract：:The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...

journal_title：Histology and histopathology

authors： Allouh MZ,Rosser BW

更新日期：2010-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...

journal_title：Histology and histopathology

authors： Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

更新日期：2010-02-01 00:00:00

abstract：:The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...

journal_title：Histology and histopathology

authors： de Oliveira BC,de Oliveira F,Martini DT,Prisco CR,da Silva Riguetti MM,Liberti EA,de Campos Boldrini S

更新日期：2010-01-01 00:00:00

abstract：:Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...

journal_title：Histology and histopathology

authors： Araújo FC,Oliveira CA,Reis AB,Del Puerto HL,Martins AS,Reis FM

更新日期：2009-12-01 00:00:00

abstract：:The present study analyzed the temporal and spatial expression of TGF-beta isoforms and activated pSmad2 and p38MAPK during epithelial debridement wound repair, using chick cornea by immunohistochemistry. Normal corneas showed low-level TGF-betas staining. Following wounding, TGF-beta1 expression was strong in the Bow...

journal_title：Histology and histopathology

authors： Huh MI,Chang Y,Jung JC

更新日期：2009-11-01 00:00:00

abstract：:HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...

journal_title：Histology and histopathology

authors： Marzioni D,Quaranta A,Lorenzi T,Morroni M,Crescimanno C,De Nictolis M,Toti P,Muzzonigro G,Baldi A,De Luca A,Castellucci M

更新日期：2009-10-01 00:00:00

abstract：:Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...

journal_title：Histology and histopathology

authors： Cejková J,Ardan T,Cejka C,Malec J,Jirsová K,Filipec M,Ruzicková E,Dotrelová D,Brunová B

更新日期：2009-10-01 00:00:00

abstract：UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...

journal_title：Histology and histopathology

authors： Goñi-de-Cerio F,Alvarez A,Alvarez FJ,Rey-Santano MC,Alonso-Alconada D,Mielgo VE,Gastiasoro E,Hilario E

更新日期：2009-09-01 00:00:00

abstract：:Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...

journal_title：Histology and histopathology

authors： Baetas-da-Cruz W,Alves L,Guimarães EV,Santos-Silva A,Pessolani MC,Barbosa HS,Corte-Real S,Cavalcante LA

更新日期：2009-08-01 00:00:00

abstract：:Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

journal_title：Histology and histopathology

authors： Bagge J,Lorentzon R,Alfredson H,Forsgren S

更新日期：2009-07-01 00:00:00

abstract：:The transport mechanism of soluble molecules throughout the interstitial matrix is closely associated with human tumor behavior in vivo. However, the examination of soluble components in histological architectures has been hampered by artifacts caused during conventional tissue preparation. In this study, the immunodi...

journal_title：Histology and histopathology

authors： Bai Y,Ohno N,Terada N,Saitoh S,Nakazawa T,Nakamura N,Katoh R,Ohno S

更新日期：2009-06-01 00:00:00

abstract：:Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

journal_title：Histology and histopathology

authors： Kitada M,Dezawa M

更新日期：2009-05-01 00:00:00

abstract：:The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...

journal_title：Histology and histopathology

authors： Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

更新日期：2009-04-01 00:00:00

abstract：:CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...

journal_title：Histology and histopathology

authors： Kim KH,Choi JS,Kim JM,Choi YL,Shin YK,Lee HC,Seong IO,Kim BK,Chae SW,Kim SH

更新日期：2009-03-01 00:00:00

abstract：:The aims of the present study were to apply the AMG technique for localization of mercury at the light and electron microscopic level in the ovary of crucian carp after exposure to mercuric chloride and to find out if this heavy metal induces expression of caspase-3. Depending on the stage of ovarian follicle developm...

journal_title：Histology and histopathology

authors： Zarnescu O

更新日期：2009-02-01 00:00:00

abstract：:We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...

journal_title：Histology and histopathology

authors： Merezhinskaya N,Fishbein WN

更新日期：2009-02-01 00:00:00

abstract：:Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...

journal_title：Histology and histopathology

authors： Yamate J,Ishimine S,Izawa T,Kumagai D,Kuwamura M

更新日期：2009-01-01 00:00:00

abstract：:In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...

journal_title：Histology and histopathology

authors： Vaquero J,Zurita M

更新日期：2009-01-01 00:00:00

abstract：AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. ME...

journal_title：Histology and histopathology

authors： Kim SH,Lee SH,Choi YL,Wang LH,Park CK,Shin YK

更新日期：2008-12-01 00:00:00

abstract：:In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

journal_title：Histology and histopathology

authors： Chuva de Sousa Lopes SM,Roelen BA

更新日期：2008-12-01 00:00:00

abstract：:Introduction. Gastrointestinal stromal tumors (GISTs) are characterized at the molecular level by c-kit or PDGFRA oncogene mutations. Although GISTs raised major interest in past decades, population-based studies are still rare. Materials and Methods. All GISTs diagnosed in Southern Switzerland (1999-2005) were identi...

journal_title：Histology and histopathology

authors： Mazzola P,Spitale A,Banfi S,Mazzucchelli L,Frattini M,Bordoni A

更新日期：2008-11-01 00:00:00

abstract：:Primary perivascular epithelioid cell tumor (PEComa) of the liver is a very rare example of an emerging family of hepatic PEC tumors. Only few cases have been described so far. We report the case of a large but benign hepatic PEComa in a 53-year-old man without signs of tuberous sclerosis. In contrast to recently desc...

journal_title：Histology and histopathology

authors： Zimmermann A,von der Brelie C,Berger B,Kappeler A,Candinas D

更新日期：2008-10-01 00:00:00

abstract：:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...

journal_title：Histology and histopathology

authors： Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua R

更新日期：2008-10-01 00:00:00

abstract：:Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...

journal_title：Histology and histopathology

authors： Bonetti A,Marchini M,Ortolani F

更新日期：2008-09-01 00:00:00

abstract：:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...

journal_title：Histology and histopathology

authors： Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were i...

journal_title：Histology and histopathology

authors： Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J

更新日期：2008-07-01 00:00:00

abstract：:The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...

journal_title：Histology and histopathology

authors： Spano A,Monaco G,Barni S,Sciola L

更新日期：2008-06-01 00:00:00

abstract：:The presence of the mu-opioid receptor and the type of glycosylation in the third extra-cellular loop of this receptor was investigated in the isthmus of mare oviduct during oestrus by means of immunoblotting and immunohistochemistry combined with enzymatic (N-glycosidase F and O-glycosidase) and chemical (beta-elimin...

journal_title：Histology and histopathology

authors： Desantis S,Albrizio M,Ventriglia G,Deflorio M,Guaricci AC,Minoia R,De Metrio G

更新日期：2008-05-01 00:00:00

abstract：:Aluminium (Al) is a neurotoxic metal and Al exposure may be a factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings in the AD brain are the presence of neuritic plaques containing beta-amyloid (Abeta) which may interfere with neuronal commu...

journal_title：Histology and histopathology

authors： Rodella LF,Ricci F,Borsani E,Stacchiotti A,Foglio E,Favero G,Rezzani R,Mariani C,Bianchi R

更新日期：2008-04-01 00:00:00